Ototoxic Drug

 | Ototoxic Medications That Cause TinnituOtotoxic medications be those that are toxic to the cochlea or vestibular (balance) structures in the ear. These medications bemuse the potential to cause enumerateening loss, tinnitus and/or dysequilibrium such as dizziness and vertigo. Ototoxicity came to the forefront of clinical heed with the discovery of streptomycin in 1944. Streptomycin was success risey used in the treatment of tuberculosis; however, a large number of patients were nominate to burgeon forth irreversible cochlear and vestibular dysfunction. Ototoxicity was also shown with the afterwards knowledge of some former(a) aminoglyco lieu antibiotics. Today, more well known pharmaceutical agents have been shown to have toxic effects on the cochleovestibular system. The list includes aminoglycosides and other antibiotics, platinum-based chemotherapy medications, salicylates, quinine and loop diuretics.The method of action of ototoxic medications differs passabl y among the heterogeneous drugs. Aminoglycosides seem to potentiate glutamate receptors in the cochlea that promote regress of tomentum cells and cochlear neurons.1 This, in turn, generates a cascade of poverty-stricken ascendent damage which leads to the destruction of hair cells and neurons.2 The damage typically begins with the inner row of outer hair cells and progresses through the other rows, then to the inner hair cells. Patients frequently develop symptoms side by side(p) the cessation of therapy. Ototoxicity-induced hearing loss tends to first unornamented in the high frequencies and often causes tinnitus. It then progressively involves the cut down frequencies and last affects speech recognition.3 Since free radical damage is telephone exchange to incapacitated hearing and vestibular disturbances, it makes sense that taking antioxidants in the lead world exposed to ototoxic medications will reduce the pOtotoxicity may be reversible or may be permanent, depend ing on the suit of medication used, dosage ! and duration of treatment. There are many other medications that...If you want to get a full essay, graze it on our website: OrderEssay.net

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